I never really got Pee-Wee. I mean, the Pee-wee's playhouse crazyness I found funny as a kid, but I never got the movies...and I have to say, I didn't get this one, either. And I LIKE stupid humor. There were a couple of scenes that got a smile out of me, but nothing that really made me laugh.
Though I have to say Joe Manganello (however you spell it) was really good. He played himself as an over-the-top slightly rediculous version of himself, and it really worked. Reminded me of Neil Patrick Harris' performance in Harold and Kumar, but in a more kid-friendly way.