RandomHero
Super Freak
I don't think there's any debate there. I think Wick has been Keanu's signature role since John Wick 3.Has John Wick surpassed Neo as Keanu Reeves' signature role?
The Matrix movies range from terrible to mediocre since the first one. The Wick movies range from great to fantastic since the first one. Regardless of how you look at the Wick movies - whether they're films you want to take seriously or just enjoy as fun stunt/action movies, they're universally considered to be not only worth the watch, but worth many rewatches.
At this point I think John Wick is far and away his #1 role. You could take Neo or Jack Traven as #2. And probably Shane Falco and Ted Logan as #4 and #5.