The Clown Prince of Crime
Super Freak
The first movie should have some lesser known antagonist like Psycho-Man or Mole Man or even Red Ghost and the Intelligencia. The second should be Galactus and introduce the Silver Surfer. Then you can give Norrin a spin-off. The third should be Annihilus. Doom ideally would be a sort of secondary protagonist instead of an antagonist, being slowly built up, and get his own show or spin-off. After the trilogy you could do Future Foundation. Keep Secret Wars to end the MCU as a whole. Maybe you could do that as a quasi 2nd trilogy. FF, then Ultimate F4 to introduce the Maker, then Secret Wars with an Illuminati film proceeding it. Seed Molecule Man throughout the whole thing. Maybe an Infamous Iron Man flick as an epilogue. Iron Man was the starting point, that could be the end. Doom gets a quasi redemption as the new Iron Man and the F4 get the final shot creating universes.
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That's cool and all, but I don't want to be in a nursing home by the time we see Dr. Doom as a main villain.