I'm guessing TOS and TNG will shoot for full bridge crews and DS9 and VOY will test the waters two characters at a time Sisko/Jadzia (DS9) Janeway/7of 9 (VOY), with remaining crew members coming on board based on sales and popularity. At least that's how I'd approach. Characters like Basheer, O'Brien, Paris and Neelix will be harder sells beyond harder core fans and completionists. I'm not factoring in Enterprise or Discovery at this point. While not bridge crew members, TOS may expand to include Nurse Chapel and Yeoman Rand, and TNG to include Guinan, Tasha Yar and Ensign Ro.
I'd also like to see QMx branch out into more iconic aliens TOS - Khan, Gorn, Salt Monster, Andorian, Orion Slave Girl; TNG - Q, Borg, Dathon, Romulan; DS9 - Gul Dukat, Weyoun, Jem Hadar, Gowron, Martok; VOY--ummm, maybe the Borg Queen.
And we can't forget the movies -- from the TOS movies I'm really only interested in Khan but certainly would pick up more crew members, Kruge, etc. From New Trek, I'd like to see Bones, Uhura, Scotty, Sulu, Chekov and maybe Carol Marcus. Nero, Khan and Jaylah.
While this seems like a ton of figures, consider what Hot Toys & Sideshow have done with Star Wars. Trek is a huge potential license with a deep catalog of characters. They've been able to sell tons action figures and other merchandise for decades, they just haven't been able to crack the 1:6 figure market. Hopefully this will change that.