Who would win in a fight between midichlorians and black goo?
I've seen some criticism of the "black goo", but it's a simplified storytelling device. Is it used well by Ridley Scott? Yes and No. I'll explain.
You cannot have a "God" or "Creator" character shown and then easily have them speak. What do they say? How do they say it? What kind of dialogue can you deploy that won't be mocked or turned into a meme? What kind of answers can they give without infuriating some subgroup of the casual viewing audience? It's close to impossible to write (Maybe Aaron Sorkin can do it, maybe if you get a generational level writer like that, but I don't even think he'd attempt it, not even in his coked up salad days) So no one writes it.
If you have major characters that can't or don't speak, then you need something visually to replace exposition. How can you have a human voice doing a voiceover like Deckard in Blade Runner talking about what Gods or Creators are doing and not have the same strange impact that will odds on backfire on you as the director, writers, actors, etc, etc?
The "black goo" is a delivery system that is simplified enough for the casual viewing audience. It's not "white goo" because the jokes and mocking would never end. It's not "red goo" because if you have an Alien using it's tail and claws to rip a human open, then how do you differentiate it with blood. If it's grey and clumpy, then people will think it's hummus. ( I've been told many of you Wonderbreads out there apparently love Trader Joe's box wine and hummus, I don't know if that's true or not. It's a bit of an unsettling thought. )
But jet black viscous liquid immediately and naturally opens up a threat profile with people. Used motor oil? What is it? OK, if it's in your food, you are clearly not going to mistake it for something good for you. You are eating some pasta or cereal and you look away, you look back and there's this black goo in the middle of your plate or bowl. OK, something is wrong.
The narrative and logistical mistake that Scott made with Prometheus, IMHO, is not the black goo. It's that you have very central critical characters who can't speak. If they can't speak, you need more extended run time with them to explain their actions/behavior/motivations without dialogue. Then you need to vastly simplify their actions into their most base levels so the audience can pick it up. And I'm talking aiming at the portions of the audience that are very low IQ ( hate to say it that way, but you can't overcomplicate your plot and critical plot devices to the point where your viewers just surrender)
Simple examples? Tartakovsky's Primal. Spear and Fang. No dialogue but simple effective storytelling. The first 10-15 minutes of Riddick in 2013. Close to no dialogue at all. What's the key there? You can't have a huge cast and pull that off. The biggest weight around the neck of Prometheus are all the humans.
Remove Vickers completely, what do you lose? Nothing. Captain Janek? Nothing. The two pilots? Nothing. The crew that were nameless cannon fodder in the hangar fight? Nothing. The mean ego driven boyfriend in Holloway? Nothing. The two scientists lost in the caves? Nothing. You can distill Prometheus down to Weyland himself, David the android, maybe add in Walter the android as well, then the Creators/Engineers and that's it. That's plenty for a film where you are going to have to carve out and isolate major sections with no dialogue. From the standpoint of an investor, or a potential one, the argument most common at that point is the audience won't stay invested in that kind of film. OK, how invested are they going to be in a disjointed movie where clearly two entirely different concepts were deployed at the same time then mashed together? You'll get moderate revenue simply for being an Alien film after a long long long wait by many fans, but you'll lose them for anything else (Which is part of why Covenant bombed so badly)
I am somewhat hesitant to criticize Ridley Scott too heavily as he generally makes solid fundamental films and has done so for a very long time. But he filmed an outline here, not a real cohesive narrative, where it was clear he needed to write it all himself and then allow it to be truly pressure tested. While it's not public, the treatment of Jon Spaihts on this film was pretty ugly. Plenty of talented writers will kill to work with Ridley Scott, but not on a future Alien film. Not the ones with real options. Not moving forward.
Screenwriting 101 - When you are stuck, truly stuck, on a long term concept, then your escape is to write a novel. One that will never be published (Or pay 10 people to write one for you, but you have to give them a cohesive and well made story bible first) Then allow real editors, with a true free hand, to try to tear it apart. Pressure test it. Then you have them revise it again and again until the concept and storyline actually makes sense. Then you adapt it into a screen play. And that method would have also helped? George Lucas in the prequel trilogy and Zack Snyder with Rebel Moon.
There are, at minimum, four very interesting concepts in Prometheus that could have become solid stand alone films. Pick one. You can't pick them all. The sheer waste of the collected acting firepower in Prometheus is unforgivable. The big pink elephant in the room is Scott should just make the film he really wants to make ( instead of this tiptoe routine with picking up Raised By Wolves and doing Prometheus) He wants to make a film that completely denounces Christianity. So just make it. Eat the fallout that comes with it if it comes to that. The beloved Alien franchise didn't need to be collateral damage to his cowardice.
Something I've said about the current Star Wars slate is that the entire franchise would be in so much better shape if Kathleen Kennedy just made the film she really wants to make - A movie about the trials, struggles and perceived triumph of Kathleen Kennedy. Just get it out of your system and allow legacy fans to stop being held hostage as your proxy to a free therapy session. Stars Wars then could attempt to truly move in a positive forward direction. Scott should just create the film he covets, where he empties his bowels all over Christians. Then we can shed all this passive aggressive undertones in his films and he can just go back to making good solid films with the little time he has left.