- If EMS is between 0-1749, only one option will be available depending on the player's choice at the end of Mass Effect 2: Control, if Shepard saved the Collector Base, and Destroy if Shepard did not. Both will result in massive physical damage to Earth, with Destroy killing almost everyone on Earth.
- If EMS is between 1750-2349, both Destroy or Control options are available, but either choice will cause some substantial damage to the galaxy.
- If EMS is between 2350-2649, the Control option will cause no physical damage but the Destroy option will still cause widespread damage.
- If EMS is 2650+ the Destroy and Control options will no longer cause any physical harm to the galaxy.
- If EMS is 2800+ the Synthesis ending becomes available.
- If EMS is 3100+ and the Destroy option is chosen, Shepard is seen barely alive, gasping for breath (if Anderson is shot by the Illusive Man, the player needs a higher EMS to see this short scene).
The Destroy (red) option will result in the destruction of all synthetic life. The Crucible will fire a beam/pulse into the mass relay network, spreading the blast across the galaxy but severely damaging every relay and the Citadel in the process. Some time later, the galaxy eventually finishes the repairs to the relays and recovers from the destruction the Reapers had caused. Admiral Hackett narrates this ending.
- If EMS is substantially low, choosing Destroy will result in massive physical damage throughout the galaxy, as well as the annihilation of most life. Hackett's narrative is different in this ending; his outlook on the galaxy's future is far more bleak.
The Control (blue) option results in Shepard sacrificing corporeality to command the Reaper fleet. The Reapers will then leave Earth at the will of the Commander. Instead of firing a beam, only a pulse will be released from the Citadel. The pulse spreads throughout the mass relay network, damaging them but leaving the Citadel intact. Shepard directs the Reapers to repair the mass relays and help rebuild the galaxy. Commander Shepard narrates this ending.
- Depending on the player's Paragon/Renegade score, Shepard's narrative changes in regards to their utilization of the Reapers.
In the Synthesis (green) ending, Shepard adds their energy to the Crucible's, thus creating a new, synthesized DNA. The Catalyst explains that this is the best option, since synthesis is the pinnacle of evolution, and will render the Reapers obsolete. The Crucible emits a green light/beam, altering all denizens of the galaxy on the genetic level; the dividing lines between synthetic and organic life are blurred. The Reapers rebuild the damaged relays of their own accord, as well as share the collective knowledge of countless lost civilizations. EDI narrates this ending.
Alternatively, Shepard can refuse to activate the Crucible. While speaking with the Catalyst, Shepard can reject deciding between the Destroy, Control, and Synthesis endings, insisting that a decision with such a massive impact on the galaxy and its people cannot be made, and that the war must end on Shepard's terms; or, Shepard can initially accept the Catalyst's options, but can then attempt to shoot the Catalyst instead. Both actions result in a Reaper victory and the continuation of the cycle of extinction. One of Liara's time capsules is then shown on an unknown world, and a recording of Liara explains that even though the people of her time failed in their struggle against the Reapers, those who find the capsule still have a chance to succeed.
In the Destroy, Control, and Synthesis endings, the Crucible's blast causes the Normandy to crash land on an unknown planet. The survival of the Normandy's crew will rely largely on EMS:
- If EMS is substantially low (below ~1750) and the Destroy ending is chosen, nobody exits the Normandy.
- If EMS is substantially low (below ~1750) and Control is chosen, Joker and two of the player's most-favored crew mates will exit a heavily damaged ship.
- If EMS is moderately high (above minimum, below maximum) and Destroy or Control are chosen, Joker and two of the player's most-favored crew mates will exit a heavily damaged ship.
- If EMS is 2800 or above, and Destroy or Control is chosen, Joker and two of the player's most-favored crew mates will exit a relatively undamaged ship.
- If Synthesis is chosen, Joker, EDI, and the player's most-favored crew member will exit the ship. Joker and EDI will embrace.
Various epilogue scenes will be shown, depicting the fates of noteworthy characters and races encountered throughout the journey. These scenes will depend on the choices made throughout the game, as well as the entire series. The surviving members of the Normandy's crew are then seen gathered near the memorial wall, honoring the memory of all those listed. The player's love interest (or Samantha if no love interest present: for example if Liara was killed by Harbinger's beam; likewise Miranda will not appear here even if she survives since she is not part of the crew) will place Commander Shepard's name plaque above Admiral Anderson's. If all crew members survived but Shepard does not have a current love interest, then the character Shepard interacted with the most will put the Commander's name on the wall. Afterwards, depending on EMS rating, the Normandy will be shown on the unknown planet, either being repaired or taking off into space.
- If the Destroy option was chosen and the player has very high EMS, the plaque is shown, but not placed on the wall (love interest smiles and doesn't place it) and a scene showing Shepard breathing in a pile of rubble is shown as the last scene before the credits roll.
After the credits, a scene will be shown in which a Stargazer tells tales of "The Shepard" to a young child