Socialized health care (i.e., no health care at all), rampant illegal immigration, no school choice for parents who want their children to get a real education (as opposed to the tripe that passes for public education), $10/gallon gasoline, a much-too-soft approach to the war on terror, expansion of abortion "rights" laws to new obscene levels, significant tax increases. And those are just the things that spring immediately to mind.
Despite what democrats seem to believe, Obama is a very divisive candidate. Of course, the press (judging by Chris Matthews' orgasmic reaction to Obama's speech last night) will spin all of these things into wonderful positives.