After a few hours with RE4, I'm kinda left disappointed. There's this lazy gaussian blur over the upscaled fonts (such as the save menu) and no anti aliasing leaves the whole game with a shimmering effect. The "new" textures don't look great slapped on old polygons and everything looks unnecessarily fake compared to the Gamecube version.
There's a motion blur option which should have really helped the game retain the atmosphere, but it's poorly implemented and looks like Vaseline smeared onto your screen. The audio is also appalling, with no discreet ambient surround effects and the custcenes are in stereo.
Finally, the controls is awkwardly stiff. They tweaked the controls without having the options to use the original GC/PS2 control scheme and it requires a lot of getting used to.
All in all, it's a step up from the PS3 version but to really have the definitive RE4, you'll still have to hook up your Gamecube/Wii via component cables to a CRT monitor for best results. It's not a bad port mind you, just an okay one.