Darth_Fatso
Super Freak
Personally I don't think so only because they are supposedly changing around gameplay and taking the story in a different direction with the next Resident Evil that I could see them letting sleeping horses lie. Wesker had a full circle story that I think he is done.
You may be right and personally as great a character as Wesker is/was, I'm fine if with that. If they do bring him back though, I just hope it's not in RE6. Too soon.
Still, I remember reading somewhere where one of the game creators said Wesker could still play some role in RE6.