The Clown Prince of Crime
Super Freak
I'm not sure a robot with Freeze's head is the best "serious" take.
A villain trapped in a life-support suit -- like bubble boy -- is realistic and could be very creepy. I think its the whole over-kill on "cold" that makes Freeze spill into "fantasy" territory.
The idea of some disease where his base temperature needs to be kept cold is very cool, and his fascination with all things cold is fine... its the living in an igloo, using an impractical freeze ray gun, etc. If they toned it down, where the idea of being cold was more about not being able to "touch" another person -- a symbolic cyborg -- which could be an interesting and foreboding tale of what is becoming of the new 'phone' generation. The loss of human contact. Man becoming Machine.
By serious, I meant the character's personality, unlike Arnold with his jokes and cold puns.
Mr Freeze would have to be a fantasy character with his freeze gun and spider head if they really want to get creepy.
I don't want a realistic take on fantasy characters like Man Bat, Clay Face, and Poison Ivy.