it all depends on the supplements. some guys i see are on t-bomb and all that crazy stuff. some guys swear by creatine. others do nothing. it depends on your goals and philosophy. my wife (mrs gnc) has me on 3 things no2 for bloodflow and recovery, creatine 189 for muscle density (doesn't require massive h2o intake), and massxxx for protein. personally, i use em cause i have the metabolism of speedy gonzalez and lose weight just sitting around the house. none of these are for bulking, they're designed for long term performance. i agree, bulking using creatine monohydrate, and various hormonal supplements to get huge by doing a few sets is cheating and hazardous.
i can only use myself and my sister in law (pro fitness model) as a guide. her goal is looks and to feel good. my goal is more tactical in nature ie, to be strong, fast, and durable enough to win a fight as fast a possible or survive as long as possible.
i apologize for the paragraphs, but i actually have invested a lot of time into the subject. i did au naturale for years before i realized i was not getting anywhere. my max wouldn't budge, my body weight was unhealthily light, my heart rate was weak. i guess it all depends on a bunch of factors.