The only thing i can think with Enrico, is he too was also being manipulated by Wesker. And much like Barry was able to kind of move about the Mansion and its surroundings freely Enrico might of knew the location of the Lab. And if he did know about the lab theres a good chance he could of accessed one of the emergency trains into its ground floor or another one of the cable cars. What he was doing there its not sure at all.The biggest plot hole in RE history comes with RE Zero. How did Enrico get the lab in Zero (which was probably the RE2 lab) which was miles and miles away not long after Rebecca while on foot and THEN hike all the way back to the crash site and find the Mansion?
But i think his speech in the underground during re 1-remake about how STARS are being brought down was more than just an assumption that he made from being shot. And then Wesker silenced him before he could spill any more info.