Rumors from 4chan (most likely ****posting, but eh):
Eddie Brock is still a disgraced journalist, but rather than the Sin Eater he was duped by Cleetus Kassady, and Kassady was brought down by Detective Jean DeWolff rather then Spider-Man himself. Kassady was also a killer-for-hire for mob boss Silvio Manfredi.
Brock finds out Kassady has been moved to the privately-funded Ravencroft Institute and breaks in to investigate, as he's obsessed with getting revenge on Kassady for ruining his life. As it turns out, Kassady is being used in experiments conducted by Dr. Miles Warren to weaponize an alien symbiote that has been recovered from a crash site by their benefactor (OsCorp). **** goes wrong, and Brock bonds with the original symbiote while Warren's "clone" bonds with Kassady.
Kassady becomes Carnage and essentially goes on a rampage, hellbent on toppling Manfredi's empire after Manfredi betrayed him. Brock grappes with the changes in his organism and a telepathlic link that allows him to sense what Carnage is up to.
Warren's assistant Ashley Kafka finds out about the whole thing. They fall in love as Ashley helps Brock overcome his issues and become Venom in order to stop Carnage while both are being hunted by both Warren and DeWolff.
Mac Gargan is featured as the leader of OsCorp's private military unit, armed with sound-based weaponry, and we also get Robbie Robertson as Brock's old editor at the Daily Goble, and Robbie Farrell as Brock's street-wise informant and friend who dies. Frankie Barrison also appears as Kassady's psycho junkie girlfriend, while Patrick Mulligan is featured as DeWolff's partner.
Spider-Man is not involved in the plot at all, but there's a passing reference to him. Just the bare minimum to establish that he might exist in that universe.
Reminder that these people are in charge:
