As a child at the age of 12 in 1944, Charles met a shape-shifting girl named Raven, who had broken into his family's mansion and was scrounging for food. Overjoyed to meet someone else "different" like him, he invited her to live with his family. Raven and Charles soon become best friends.
A natural genius, Charles attended Oxford University (accompanied by Raven, now his foster sister), earning a Ph.D in Genetics. After completing his thesis on genetic mutation at age 24, he is approached by Agent Moira MacTaggert of the CIA for his help to stop a mutant named Sebastian Shaw,